Long-Acting Opioids and Short-Acting Opioids: Appropriate Use in Chronic Pain Management
نویسندگان
چکیده
منابع مشابه
Are Long-Acting Opioids More Effective Than Short-Acting Opioids for Chronic Pain?
A new study calls into question the view that extended-release/long-acting (ER/LA) opioids are more effictive than immediate-release/short-acting (IR/SA) formulations for the management of chronic pain.1 The acceptance of the purported benefits of ER/LA opioids is understandable for patients whose pain is continuous and fairly constant over the course of the day. As an accompanying editorial to...
متن کاملHypogonadism in men with chronic pain linked to the use of long-acting rather than short-acting opioids.
AIM There is a need to elucidate the variables associated with testosterone suppression among men on daily opioid therapy for chronic pain. OBJECTIVE The objective of this study was to examine several variables related to opioid use including daily dose, duration of action (long acting vs. short acting), and specific opioid to ascertain specific influences on total serum testosterone levels i...
متن کاملPeripherally-acting opioids.
Opioids are broad-spectrum analgesics with potent pain-relieving qualities but also with potential adverse effects related to both short-term and long-term therapy. Researchers have attempted to alter existing opioid analgesics, utilize different routes/formulations, or combine opioid analgesics with other compounds in efforts to improve analgesia while minimizing adverse effects. Exogenous opi...
متن کاملTargeting pain and inflammation by peripherally acting opioids
INTRODUCTION Opioids can produce potent analgesia by activating opioid receptors outside the central nervous system, thus avoiding centrally mediated unwanted effects. Peripheral opioid receptors are expressed in peripheral sensory (dorsal root ganglion) neurons and can interact with exogenous or endogenous opioid ligands both in animals and in humans. Inflammation of peripheral tissue leads to...
متن کاملPeripherally acting opioids and clinical implications for pain control.
Opioid receptors are widely expressed in the central and peripheral nervous system and in the non-neuronal tissues. Data from animal and human clinical studies support the involvement of peripheral opioid receptors in analgesia, especially in the presence of inflammation. Inflammation has been shown to increase the synthesis of opioid receptors in the dorsal root ganglion neurons and enhance tr...
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ژورنال
عنوان ژورنال: Pain Medicine
سال: 2009
ISSN: 1526-2375,1526-4637
DOI: 10.1111/j.1526-4637.2009.00666.x